A gold( iii )-catalyzed Conia-ene reaction for the direct synthesis of substituted pyrroles from β-ketopropargyl amines

Key Points

• Polysubstituted pyrroles are synthesized via a gold-catalyzed reaction of β-ketopropargyl amines, demonstrating efficiency.
• The reaction shows distinct structure-reactivity trends when varying the substituents, indicating precise control over outcomes.
• Application of the method successfully leads to the formation of bicyclic indolizine rings from the targeted substrates through a telescoping sequence.
• These findings highlight gold catalysis as a viable approach for synthesizing complex amine derivatives, with potential implications in organic chemistry.

Abstract