Age‐Related Genetic Causal Association Between Asthma and Delirium: A Bidirectional Two‐Sample Mendelian Randomization

Key Points

• The analysis does not support a genetic causal association between asthma and delirium, indicating non-genetic influences may play a role.
• Key confounders were addressed in the model, ensuring robust comparisons across age-related asthma subtypes without identifying a direct link.
• Bidirectional Mendelian randomization (MR) and multivariable MR (MVMR) methods were used to test the associations in this comprehensive analysis.
• Findings highlight the need for further studies integrating clinical and biomarker data to better understand the relationship between these conditions.

Abstract