Strategies for blood–brain barrier rejuvenation and repair

Key Points

• Rejuvenation of the blood-brain barrier enhances neuroprotective functions, and reduces neuroinflammation—key factors in neurodegeneration.
• Evidence suggests interventions targeting molecular pathways can restore normal blood-brain barrier function, improving neurological outcomes.
• This observational analysis focuses on strategies to repair the blood-brain barrier by employing various therapeutic interventions for neurodegenerative conditions.
• Highlighting the need for further exploration, these findings indicate that restoring the blood-brain barrier may significantly improve brain health.