March 3, 2026Open Access

Immunohistochemistry as a tool for identifying EGFR amplification in CNS tumors

Key Points

EGFR immunohistochemistry is highly specific and sensitive for identifying amplification in glioblastoma.
Key evidence shows its usage can significantly improve diagnostic accuracy in brain tumors, particularly glioblastoma.
Observational analysis across CNS tumor samples revealed the potential of immunohistochemistry as a routine diagnostic tool.
This finding highlights the importance of incorporating immunohistochemistry in neuropathology to enhance diagnostic protocols.

Abstract

EGFR gene amplification constitutes a diagnostic hallmark for glioblastoma, IDH-wildtype (GB, IDH-WT). Herein, we demonstrated that EGFR IHC is a highly specific and sensitive biomarker for identifying EGFR amplification and should be part of the neuropathologist's routine panel of antibodies.

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Authors

Arnault Tauziède‐Espariat

Mary Bah

Farah Sassi

Journals

Brain Pathology

Actions

Institutions

Inserm

Université Paris Cité

Centre Hospitalier Sainte-Anne

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Immunohistochemistry as a tool for identifying EGFR amplification in CNS tumors

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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