miRNAs mediated Hsa21 gene suppression as potential therapeutic agent for Down syndrome: molecular dynamics and MM/PBSA-based study

Key Points

• Gene suppression has potential as a therapeutic approach for Down syndrome, focusing on miRNAs.
• Analysis shows that molecular dynamics simulations highlight the role of miRNAs in regulating gene activity.
• The study employs MM/PBSA methods to assess interactions between miRNAs and Hsa21 genes in detail.
• Understanding these interactions may enable future development of targeted treatments for Down syndrome.