Genome-wide investigation highlights global and local pleiotropy linking neurodevelopmental disorders to acquired hearing problems

Key Points

• Comorbidity between neurodevelopmental disorders and acquired hearing problems indicates shared mechanisms.
• Evidence reveals that both intrinsic and extrinsic factors contribute to the observed relationships.
• Analysis highlights potential genetic links through genome-wide approaches, emphasizing pleiotropy.
• Shared pathogenic processes may inform future strategies for intervening in both disorder types.

Abstract