March 3, 2026

Patients With Bw4 and Bw6 Antibodies Can Participate in Clinical Xenotransplantation Trials

Key Points

Cross-reactivity with anti-Bw4 and anti-Bw6 antibodies is not present in certain pigs' SLA.
Incorporating epitope-level testing may enable access for highly sensitized individuals to xenotransplantation.
Assessment used detailed histocompatibility testing for effective transplantation solutions in sensitized patients.
This approach may open new pathways for those with specific antibody sensitivities, enhancing organ availability.

Abstract

These findings indicate that the SLA of at least some pigs will not exhibit cross-reactivity with anti-Bw4 and anti-Bw6 antibodies. Incorporating detailed, epitope-level histocompatibility testing may allow these highly sensitized patients, access to xenotransplantation.

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Discussion

Authors

Sabrina Copsel

Bryan Ray

Jayasree Hariharan

Journals

Transplantation

Actions

Institutions

Northwestern University

University of Miami

Io Therapeutics (United States)

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Patients With Bw4 and Bw6 Antibodies Can Participate in Clinical Xenotransplantation Trials

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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