Is there a directional genetic and transcriptomic association between major depressive disorder and the risk of myocardial infarction and heart failure?
Populations analyzed for Major Depressive Disorder (MDD), Myocardial Infarction (MI), and Heart Failure (HF) using genetic, epidemiological, and multi-omic data
Directional association between MDD and risk of MI and HF, and identification of blood-based gene panels and immune endotypessurrogate
Mendelian randomization and transcriptome analysis identify a directional association between depression and increased risk of MI and HF, revealing specific immune endotypes as potential therapeutic targets.
Genetic, epidemiological, and multi-omic evidence supports a directional association between MDD and increased risk of MI and HF. We deliver reproducible blood-based gene panels and immune endotypes that dissect biologically distinct MDD-CVD substructures, offering actionable targets for precision immunomodulatory therapy in cardio-depressive comorbidity.
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Zihao Zhou
Xue‐Zhong Yu
Yani Jin
Frontiers in Immunology
Zhejiang University
Sir Run Run Shaw Hospital
Chengdu University of Traditional Chinese Medicine
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Zhou et al. (Thu,) studied this question.
www.synapsesocial.com/papers/69a75c6dc6e9836116a254e8 — DOI: https://doi.org/10.3389/fimmu.2026.1727699