Rhein Inhibits NLRP3 Activation and Alleviates Microglial Pyroptosis After Intracerebral Hemorrhage in Rats

Key Points

• Rhein alleviates neurological dysfunction by reducing microglial pyroptosis and mitigating neuroinflammation after intracerebral hemorrhage.
• The most significant finding shows decreased NLRP3 inflammasome activation in the treatment group, linked to improved symptoms.
• Assessment using a rat model of intracerebral hemorrhage shows that rhein administration leads to notable recovery signs.
• These findings may enable further exploration of rhein's therapeutic potential in treating neuroinflammatory conditions.

Abstract