Does Global Longitudinal Strain (GLS) improve screening for chemotherapy-induced cardiotoxicity in breast cancer compared to isolated Left Ventricular Ejection Fraction (LVEF) assessment?
Breast cancer patients at risk for chemotherapy-induced cardiotoxicity
Global Longitudinal Strain (GLS) assessment
Isolated assessment by Left Ventricular Ejection Fraction (LVEF)
Screening/detection of cardiotoxicitysurrogate
Global Longitudinal Strain (GLS) is recommended as the preferred imaging modality over isolated LVEF for detecting chemotherapy-induced cardiotoxicity in breast cancer.
Comparative analysis of data from our meta-analyses supports the recommendation of Global Longitudinal Strain (GLS) as the preferred method for screening for cardiotoxicity, over isolated assessment by Left Ventricular Ejection Fraction (LVEF).
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Linhares et al. (Wed,) studied this question.
www.synapsesocial.com/papers/69a75c8ac6e9836116a257ed — DOI: https://doi.org/10.1016/j.cpcardiol.2026.103289
Bruno Gama Linhares
Diego Gama Linhares
Rodrigo Gomes de Souza Vale
Current Problems in Cardiology
Universidade do Porto
Universidade do Estado do Rio de Janeiro
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