March 3, 2026Open Access

ClC ‐2 Contributes to Hypotonicity‐Induced Adrenal Aldosterone Secretion

Key Points

Aldosterone secretion increases with hypotonicity, driven by ClC-2 activity and calcium influx.
Data indicate that ClC-2 influences chloride outflow, affecting cellular depolarization and calcium dynamics.

Structured PICO

Population

Adrenal zona glomerulosa (ZG) cells

Intervention

Reduced extracellular osmolality (hypotonicity)

Outcome

Aldosterone secretion/production, chloride outflow, depolarization, and voltage-dependent calcium influxsurrogate

ClC-2 channels mediate hypotonicity-induced aldosterone production in adrenal zona glomerulosa cells via chloride outflow and subsequent depolarization.

Abstract

ClC-2 plays a role in the ZG's response to reduced extracellular osmolality through chloride outflow, which likely causes depolarization, voltage-dependent calcium influx, and aldosterone production. These data advance our understanding of regulators of aldosterone production.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Marina Volkert

Hoang An Dinh

Kerim Mutig

Journals

Acta Physiologica

Actions

Institutions

Charité - Universitätsmedizin Berlin

Berlin Institute of Health at Charité - Universitätsmedizin Berlin

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

ClC ‐2 Contributes to Hypotonicity‐Induced Adrenal Aldosterone Secretion

Key Points

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study