Antigen-specific T Cell precursor frequency influences the proliferation of stem-like T Cells in tumor-draining lymph nodes and anti-tumor immune responses

Key Points

• Initial precursor frequencies of tumor-antigen-specific T cells significantly influence stem-like T cell dynamics.
• Higher precursor frequencies lead to enhanced proliferation of stem-like T cells in tumor-draining lymph nodes.
• The analysis uncovers a mechanism behind response variability to anti-PD-1 immunotherapy.
• Understanding this link may provide insights for developing strategies against immune checkpoint blockade resistance.

Abstract