Inhibiting H3K18 lactylation in microglia aggravates white matter injury after intracerebral hemorrhage in mice

Key Points

• White matter injury is worsened by inhibiting h3k18 lactylation in microglia after intracerebral hemorrhage, indicating its protective role.
• The critical protective axis involves lactate, p300/CBP, and h3k18 lactylation, highlighting an achievable neuroprotective strategy.
• Assessment utilizing epigenetic markers and microglial activity underscores the intricate cellular mechanisms at play in brain repair.
• Targeting this h3k18 lactylation pathway may enhance recovery post-intracerebral hemorrhage, but further studies are necessary.

Abstract