Validation of the European SCORE2 algorithm in one European and one Latin-American cohort studies with contrasting populations

Key Points

• SCORE2's prediction of cardiovascular disease showed varied accuracy between cohorts, with recalibration needed for the Portuguese group.
• It performed adequately in the Mexican cohort, indicating population-specific factors influence risk prediction.
• Analysis across two contrasting populations highlights the importance of local adjustments to prediction algorithms.
• Recalibration may enhance SCORE2's effectiveness in diverse populations, addressing disparities in cardiovascular risk assessment.

Abstract