March 3, 2026Open Access

Reply to “Comment on ‘De Novo Reconstruction of 3D Human Facial Images From DNA Sequence’”

Key Points

Clarification of the methodological rationale behind DNA-based 3D facial images is provided, addressing major misconceptions.
Significant points include a detailed explanation of analytical procedures originally used for modeling facial images.
The discussion emphasizes the ethical governance and intended limitations of the technology, especially in predictive modeling.
Ongoing efforts focus on enhancing the interpretability and scientific rigor of DNA-based facial predictions.

Abstract

This manuscript is a formal response to the Comment by Wagner et al. regarding our publication "De Novo Reconstruction of 3D Human Facial Images from DNA Sequence." We clarify the methodological rationale, analytical procedures, and scientific scope of our original study, and we address several misconceptions arising in the Comment. We further highlight the intended purpose and limitations of Difface and discuss ongoing efforts to advance the rigor, interpretability, and ethical governance of DNA-based 3D facial prediction.

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Cite this study

Jiao et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69a75cd0c6e9836116a25fd8 — DOI: https://doi.org/10.1002/advs.73979

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Matching 3D Facial Shape to Demographic Properties by Geometric Metric Learning: A Part-Based Approach

Authors

Mingqi Jiao

Jiarui Li

Chunman Zuo

Journals

Advanced Science

Actions

Institutions

Shanghai Jiao Tong University

Sun Yat-sen University

ZheJiang Academy of Agricultural Sciences

References and Citations

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Reply to “Comment on ‘De Novo Reconstruction of 3D Human Facial Images From DNA Sequence’”

Key Points

Abstract

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Discussion

Cite this study

Also consider

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

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Discussion