Accueil
Explorer
nav.journalClub
Tendances
Plus
synapse
⌘+K
Langue
Français
March 3, 2026
Open Access
ZDHHC4-mediated ZEB-2 S-palmitoylation promotes melanoma epithelial-mesenchymal transition via deubiquitinating and stabilizing ZEB-2
SC
Shisong Chen
Shanghai Chest Hospital
HS
Hanyu Shen
Wuxi People's Hospital
HZ
Huiying Zhang
Burn Institute
See all
Key Points
Melanoma epithelial-mesenchymal transition is promoted by ZDHHC4-mediated ZEB-2 s-palmitoylation.
Key evidence shows that ZEB-2 levels significantly increase, indicating its crucial role in transition processes.
Analysis of ZDHHC4 functions reveals its role in deubiquitinating and stabilizing ZEB-2, enhancing its activity.
Highlights the potential of targeting ZDHHC4 for melanoma therapeutics, though limits exist in current models.
Read Full Paper
externally
Mark Helpful
Like
Save
Bookmark
Relay
Share
View Full Paper
Mark Helpful
Like
Save
Bookmark
Relay
Share
View Full Paper
Cite This Study
Copy
Chen et al. (Wed,) studied this question.
synapsesocial.com/papers/69a75ce7c6e9836116a262ad
https://doi.org/https://doi.org/10.1007/s00018-025-05974-5
ZDHHC4-mediated ZEB-2 S-palmitoylation promotes melanoma epithelial-mesenchymal transition via deubiquitinating and stabilizing ZEB-2 | Synapse