Association of splenic contraction with stroke severity and diabetes mellitus in patients with acute ischemic stroke

Patients with SC demonstrated significantly higher admission NIHSS scores, suggesting that SC is associated with greater neurological deficits during the acute phase of ischemic stroke. DM was associated with a lower incidence of post-stroke SC, possibly due to DM-associated pathophysiology such as blunted sympathetic response or oxidative stress-induced splenic dysfunction. These findings emphasize the potential role of the spleen in stroke pathophysiology and highlight its potential as a therapeutic target.