March 3, 2026Open Access

T‐Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues

Key Points

T-cell signaling pathways and exhaustion are predominant in unhealthy adipose tissues.
The study utilized an unbiased clustering approach on transcript data to identify metabolic adaptations.

Structured PICO

Population

Transcript data from subcutaneous adipose tissue (SAT) and visceral adipose tissue (VAT)

Intervention

Unbiased clustering approach and creation of continuous metabolic syndrome (MetS) scores

Outcome

Identification of predominant signaling pathways in metabolically unhealthy adaptationssurrogate

Transcriptomic analysis reveals that T-cell signaling and exhaustion are key features of metabolically unhealthy adaptations in both visceral and subcutaneous adipose tissue.

Abstract

T-cell signaling and exhaustion predominate in metabolically unhealthy adaptations of both SAT and VAT. This novel handling of transcript data using an unbiased clustering approach and the creation of continuous MetS scores lead to new insights regarding adipose depot responses and T-cell biology.

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Discussion

Cite this study

Puppala et al. (Wed,) studied this question.

www.synapsesocial.com/papers/69a75d07c6e9836116a266ef — DOI: https://doi.org/10.1002/oby.70133

Authors

Sobha Puppala

Alyssa R. Hamann

Christina M. Stevens

Journals

Obesity

Actions

Institutions

Wake Forest University

University of Tasmania

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

T‐Cell Signaling Pathways, Including Exhaustion, Predominate in Unhealthy Visceral and Subcutaneous Adipose Tissues

Key Points

Structured PICO

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion