Exogenous MOTS-c mitigates myocardial ischemia–reperfusion injury: experimental and in silico evidence from rat heart models

Key Points

• Exposure to exogenous MOTS-c significantly mitigated myocardial ischemia–reperfusion injury in rat heart models, highlighting its potential for cardiac protection.
• The key metric shows a marked decrease in injury markers with a 40% reduction in cell death during reperfusion phases.
• Experimental and in silico analyses were conducted using rat heart models to assess the cardioprotective effects of exogenous MOTS-c.
• The findings suggest exogenous MOTS-c may offer an innovative approach to mitigate damage from heart attacks, prompting further investigation.