Systematic design of polybasic nanogels: influence of hydrophobic monomers on tunable physicochemical and biological properties

Key Points

• Enhanced biological properties observed, indicating significant design implications for nanogels.
• Hydrophobic monomers were shown to tune physicochemical properties significantly, affecting gel stability and functionality.
• Systematic design approach enabled the creation of polybasic nanogels with adjustable characteristics for diverse applications.
• Findings highlight potential for tailored drug delivery systems, necessitating further exploration in clinical settings.