Targeting Thioredoxin Reductase 1 Alleviates Severe Acute Pancreatitis by Modulating Oxidative Stress and Ferroptosis-Related Pathways

Key Points

• Targeting thioredoxin reductase 1 reduces oxidative stress, improving outcomes in severe acute pancreatitis.
• In models of severe acute pancreatitis, intervention lowers indicators of ferroptosis, a key oxidative process.
• Analysis of biomarkers related to oxidative stress pathways supports the role of thioredoxin reductase 1 in therapy development.
• Findings suggest thioredoxin reductase 1 may represent a novel intervention point in managing severe acute pancreatitis.