Achieving performance improvement of PAT in continuous powder blending process: A collective consideration of sampling interface design and chemometrics

Key Points

• Performance improvement of process analytical technology is critical for optimizing blending outcomes, and effective sampling interfaces enhance results.
• Analysis of various sampling interfaces indicates significant enhancement in method accuracy and efficiency for powder blending applications.
• The study assesses the role of chemometrics in refining process analytical technology during continuous powder blending, highlighting the importance of design considerations.
• Effectively refining sampling interfaces may enable more reliable outcomes in powder blending processes, indicating potential for broader application.