HHcy promotes hypertension by activating ferroptosis via suppression of the renal H₂S-SLC7A11/GPX4 axis

Key Points

• Hypertension is promoted by the activation of ferroptosis due to hhcy.
• Key evidence shows reduced h2s and decreased slc7a11 that correlate with increased blood pressure.
• This assessment uses an experimental model with a focus on renal oxidative stress pathways.
• These insights highlight novel interventional strategies targeting the h2s-slc7a11/gpx4 axis in hypertension management.