Long non-coding RNA LINC00092 inhibits esophageal squamous cell carcinoma progression by promoting ferroptosis through the MAZ/NFE2L2 axis

Key Points

• LINC00092 inhibits cancer progression through the MAZ/NFE2L2 axis and promotes ferroptosis—an important cell death pathway.
• Inhibition of esophageal squamous cell carcinoma progression was proven through in vitro experiments with ESCC cells.
• Assessment reveal tumor-suppressive effects linked to long non-coding RNA LINC00092's action on key molecular pathways.
• Potential therapeutic implications suggest further investigation into LINC00092 as a target for treating esophageal squamous cell carcinoma.

Abstract