March 3, 2026Open Access

A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity

Key Points

Mismatch negativity is altered in Kalrn-PT mice, suggesting a connection to dendritic morphology.
Kalrn's longer isoforms appear influential in the supragranular layers of the neocortex.
Observational analysis highlights structural and functional phenotypes linked to adolescent-onset changes.
Findings suggest Kalrn's critical role in sensory cortical integration, requiring further exploration in models.

Abstract

These results highlight alterations in higher-level sensory cortical integration in Kalrn-PT mice and demonstrate that adolescent-onset, disease-relevant structural and functional phenotypes can be linked by a common upstream effector. Further, these alterations appear restricted to supragranular layers, demonstrating an outsized role for Kalrn, particularly longer isoforms, in superficial neocortex.

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Authors

Anna M Rader Groves

Connor G. Gallimore

Valentina J. Sutton

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Institutions

New York University

University of Pittsburgh

Georgia State University

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A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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