Innovative mucoadhesive silk sericin/xanthan gum/polystyrene sulphonate (TSP-XNTG-g-PSS) based composites for vaginal delivery featuring instant spermicidal activity

Key Points

• Instant spermicidal activity was observed with the new mucoadhesive composites in vitro, enhancing contraceptive effectiveness.
• Composites include silk sericin, xanthan gum, and polystyrene sulphonate, combining biocompatibility and efficacy.
• Using innovative mucoadhesive technology, the composites adhere to the vaginal wall, increasing drug retention.
• May enable new approaches in vaginal delivery systems; further clinical testing needed to validate effectiveness.