Antibiotic resistance genes against “last-resort” antibiotics within the One Health framework: Dissemination, mechanisms, and AI-driven opportunities

Key Points

• Antibiotic resistance genes against last-resort antibiotics are spreading globally, complicating treatment options and public health.
• The analysis identifies key mechanisms of resistance, enabling targeted strategies to combat these challenging infections.
• Focus on the One Health framework integrates human, animal, and environmental health, allowing for a comprehensive approach to surveillance.
• AI-driven opportunities may offer innovative solutions to track and mitigate the dissemination of resistance genes, requiring interdisciplinary efforts.