Partially neutralized polyacrylate as a mucoadhesive polymer for gastroretentive delivery of a weakly basic drug: mechanistic study and in vivo evaluation

Key Points

• Gastroretentive delivery improves drug retention in the stomach, enhancing absorption rates.
• The use of partially neutralized polyacrylate shows a significant increase in mucoadhesion, optimizing drug delivery.
• In vivo evaluation demonstrated enhanced pharmacokinetics compared to traditional delivery methods in animal models.
• The study highlights the potential of mucoadhesive polymers in improving therapeutic outcomes for weakly basic drugs.