USP18 improves mitochondrial homeostasis by stabilizing PKM2 and promoting M2 polarization in macrophages to relieve acute lung injury

Key Points

• M2 polarization of macrophages was significantly enhanced, leading to improved lung function.
• The stabilization of PKM2 was crucial for maintaining mitochondrial homeostasis during the process.
• Observation focused on macrophage behavior and state changes in relation to acute lung injury.
• The findings support using USP18 as a promising target for therapeutic interventions in lung conditions.