A multilayered integrated analysis of insomnia-related genes ATG7 and JAK2 in the autophagy-inflammation mechanism and clinical implications in major depressive disorder

Key Points

• Insomnia-related genes ATG7 and JAK2 are linked to autophagy and inflammation processes.
• The analysis highlights significant interactions involving these genes in major depressive disorder.
• Observational analysis of gene expressions and their pathways in various clinical contexts.
• These findings support the potential for new targeted therapies addressing both insomnia and depression.