Aspergillus fumigatus in mechanically ventilated pneumonia— independent mortality risk and synergistic microbiome signatures from a multicenter mNGS cohort

Puntos clave

• Aspergillus fumigatus is linked with increased mortality risk in patients with mechanically ventilated pneumonia.
• The study reveals that certain microbiome signatures are synergistic with the presence of Aspergillus fumigatus, raising concerns for these patients.
• This analysis employed multicenter metagenomic next-generation sequencing (mNGS) to explore the relationship between pathogens and mortality risk.
• Findings highlight the need for targeted strategies in managing mechanically ventilated pneumonia—impacting treatment approaches.