Identification of CXCL12 as a key gene of trophoblast and endometrial stromal cell decidualization in pregnancy via scRNA-seq and experimental validation

Key Points

• CXCL12 significantly enhances proliferation and migration in trophoblast cells with implications for pregnancy outcomes.
• The study observes the involvement of the CXCL12/CXCR4 axis in reproductive health issues like recurrent miscarriage, with potential treatment avenues.
• Experimental validation paired with single-cell RNA sequencing provides robust insights into cellular interactions during decidualization.
• Findings highlight CXCL12 as a potential therapeutic target, warranting further studies to explore its role in pregnancy-related complications.

Abstract