Cord blood natural killer cell-derived extracellular vesicles inhibit Zika virus infectivity through ITGB2/perforin-mediated envelope disruption in vitro and in vivo

Key Points

• Zika virus infectivity is significantly inhibited through mechanisms involving itgb2 and perforin from extracellular vesicles.
• A reduction in viral load is observed, with a 70% decrease in infectivity in vitro and a notable reduction in vivo.
• Assessment using natural killer cell-derived extracellular vesicles reveals their role in disrupting the viral envelope.
• This analysis highlights the potential for extracellular vesicles as a novel therapeutic approach to combat Zika virus infection.