March 3, 2026Open Access

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

Key Points

Air pollution activates inflammatory pathways, hindering neurogenesis in the hippocampus, which affects cognitive abilities.
GSM-15606 reverses inflammation in glial cells without affecting neural stem cells, indicating targeted cellular effects.
Analysis of the protective role of GSM-15606 against pollution-induced damage reveals potential for therapeutic interventions.
This approach highlights the importance of specific cellular mechanisms, though it requires further validation in clinical settings.

Abstract

AirPoll activates divergent inflammatory pathways across hippocampal cell populations and suppresses neurogenesis. Targeting inflammation with GSM-15606 selectively reverses glial but not neural stem cell responses, highlighting cell-type-specific mechanisms and potential therapeutic pathways to mitigate pollution-related cognitive vulnerability. These results support GSM-15606 as a protective agent against AirPoll-induced hippocampal dysfunction and amyloidogenic stress.

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Discussion

Authors

Mohammad Shariq

Wanqing Pan

Xiran Chen

Actions

Institutions

University of Southern California

Neurological Surgery

Broad Center

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Single cell profiling reveals GSM-15606 attenuates air pollution-induced inflammation and preserves hippocampal neurogenesis

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

Cite this study

Also consider