Network pharmacology integrated with multi-omics demonstrates that Wumei Wan modulates the progression of colorectal cancer by regulating the focal adhesion-YAP signaling axis

Key Points

• Wumei Wan intervention alters inflammation-related signaling pathways, impacting colorectal cancer progression.
• The study observed significant changes in cell proliferation and extracellular matrix remodeling due to treatment.
• An integrated approach using network pharmacology and multi-omics was employed to investigate the signaling mechanisms.
• Findings support the exploration of traditional Chinese medicine in targeting cancer-related pathways, indicating broader applications.

Abstract