Neurotoxicity Mechanisms of Per- and Polyfluoroalkyl Substances: An Integrated Study of Network Toxicology, Molecular Docking, and Mendelian Randomization

Key Points

• Neurotoxicity mechanisms were characterized, revealing significant pathways linked to per- and polyfluoroalkyl substances.
• The study uses molecular docking to analyze interactions, which demonstrates binding affinities in neurotoxic pathways.
• Network toxicology approaches integrate various data sources, resulting in comprehensive insight into the health impacts of these substances.
• Findings highlight the need for further investigation into exposure-related risks tied to per- and polyfluoroalkyl substances.