Metabolic perturbations associated with per- and polyfluoroalkyl substances and their relationships with glycated hemoglobin in the Dutch PIAMA birth cohort

Key Points

• Glycated hemoglobin levels increase in children exposed to per- and polyfluoroalkyl substances (PFAS), indicating metabolic disturbances.
• Children with higher PFAS exposure show a significant average increase in glycated hemoglobin of 0.5%, potentially influencing long-term health outcomes.
• Observational analysis within the Dutch PIAMA birth cohort highlights the relationship between PFAS exposure and metabolic perturbations.
• Findings underscore the need for further investigation into PFAS exposure and metabolic health in vulnerable populations.