March 3, 2026Open Access

Hereditary diffuse gastric cancer: between underdiagnosis and overtreatment: a case series

Key Points

Timely genetic testing enhances early diagnosis and management of hereditary diffuse gastric cancer (HDGC), reducing risks.
Assessment of family history plays a crucial role in identifying individuals at high risk for HDGC.
A multidisciplinary approach that includes clinical genetics, surgery, and endoscopy is essential for effective treatment.
Optimizing risk-reducing strategies may significantly improve outcomes for high-risk carriers of HDGC.

Abstract

This case series underscores the clinical heterogeneity of HDGC and the critical role of timely genetic testing, family history assessment, and early prophylactic gastrectomy in high-risk carriers. A multidisciplinary approach integrating clinical genetics, surgery, and endoscopic expertise is essential to optimize risk-reducing strategies and outcomes in HDGC.

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Discussion

Authors

A Cavallaro

Antonio Zanghì

Paolo Di Mattia

Journals

Frontiers in Surgery

SHILAP Revista de lepidopterología

Actions

Institutions

Ospedali Riuniti Umberto I

Policlinico Universitario di Catania

Mediterranean University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Hereditary diffuse gastric cancer: between underdiagnosis and overtreatment: a case series

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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