March 3, 2026Open Access

Immunomodulatory properties of human dental pulp stromal cells: the role of IL-6/JAK/STAT3 pathway and PD-L1

Key Points

Activation of the il-6/pd-l1 axis is crucial in inflammatory responses, affecting disease progression.
We found that disruption in this axis may lead to chronic inflammatory disorders.
Analysis involved examining human dental pulp stromal cells and their interactions under inflammatory conditions.
Understanding this mechanism may enable new therapies for autoimmune diseases.

Abstract

Our study demonstrates the activation of the IL-6/PD-L1 axis in response to inflammatory conditions and underscores its potential significance in autoimmune diseases since a dysfunction of this mechanism could lead to the onset and progression of chronic inflammatory disorders.

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Cite this study

Tinco et al. (Fri,) studied this question.

www.synapsesocial.com/papers/69a75ebec6e9836116a29a35 — DOI: https://doi.org/10.3389/fimmu.2026.1713704

Authors

Rosanna Di Tinco

Alessandra Pisciotta

Giulia Bertani

Journals

SHILAP Revista de lepidopterología

Frontiers in Immunology

Actions

Institutions

Istituti di Ricovero e Cura a Carattere Scientifico

University of Modena and Reggio Emilia

Edinburgh Cancer Research

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Immunomodulatory properties of human dental pulp stromal cells: the role of IL-6/JAK/STAT3 pathway and PD-L1

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Cite this study

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion