Intergenerational and organ-specific alterations in mitochondrial DNA copy number following preconception irradiation

Key Points

• Mitochondrial DNA copy number alterations occurred in multiple organs, highlighting intergenerational effects.
• Significant changes were observed, with an average 30% decrease in DNA copy number within affected tissues.
• Observational analysis across organ-specific evaluations demonstrated the impact of preconception irradiation.
• These findings indicate that preconception exposure could influence mitochondrial DNA levels in subsequent generations.