Cerebral cavernous malformations in pregnancy: A systematic review of case reports and case series of hemorrhagic risk and outcomes

Key Points

• Pregnancy is associated with substantial hemorrhagic risk in individuals with cerebral cavernous malformations.
• A review of 25 cases indicates a notable hemorrhage rate of 36% during pregnancy.
• Observational analysis of case reports and case series highlights the varied outcomes of these malformations.
• Findings suggest close monitoring of pregnant individuals with cerebral cavernous malformations to mitigate risks.