March 3, 2026Open Access

Nanobody MET CAR-T cells show efficacy in solid tumors

Key Points

Efficacy of VHH-CAR-T cells has been demonstrated in combatting solid tumors effectively.
The quantifiable advantages include their small size and stability, leading to reduced tonic signaling.
Analysis involves advanced CAR-T design focusing specifically on solid tumor treatment.
Implications support the potential for using VHHs in future cancer therapies, warranting further exploration.

Abstract

With the multiple advantages of VHHs including small size, stability, and low potential for tonic signaling, VHH-CAR-T cells represent a promising approach for CAR-T design against solid tumors.

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Authors

Po‐Han Chen

Qin Li

Sam Devereaux

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Institutions

Yale University

University College London

Yale Cancer Center

References and Citations

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Building similarity graph...

Analyzing shared references across papers

Nanobody MET CAR-T cells show efficacy in solid tumors

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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