Trajectory of weight regain after cessation of GLP-1 receptor agonists: a systematic review and nonlinear meta-regression

Key Points

• Weight regain occurs significantly after discontinuation of GLP-1 receptor agonists, indicating a need for effective transition strategies.
• The analysis indicates nonlinear trajectories for weight regain, showing that changes in weight differ over time and based on prior treatment length.
• Systematic review methodology was employed to assess various studies regarding the weight dynamics post-treatment of GLP-1 receptor agonists.
• These findings highlight the importance of tailored interventions to support sustained weight management after treatment cessation.