The binding of HIRRV phosphoprotein to TBK1 suppressed IRF3 phosphorylation to facilitate viral replication in HINAE cells

Key Points

• Suppression of IRF3 phosphorylation facilitates viral replication in HINAE cells, highlighting a specific pathway.
• Inhibition of IRF3 phosphorylation was found to enhance viral replication, suggesting a notable interaction.
• Analysis shows a direct binding between HIRRV phosphoprotein and TBK1, affecting host immune response.
• This finding may indicate a viral evasion strategy, calling for deeper insights into antiviral mechanisms.