March 3, 2026Open Access

Efficacy and Safety of Letrozole, Misoprostol and Their Combination in First Trimester Missed Miscarriage: A randomised clinical trial

Key Points

Combination therapy improves complete miscarriage rates while maintaining tolerable safety.
Letrozole alone is associated with safer outcomes but shows lower effectiveness in miscarriage management.
Randomised clinical trial assessed the relative efficacy and safety of letrozole, misoprostol, and their combination.
Combination therapy could provide an optimal, non-invasive option for individualized care during missed miscarriage.

Abstract

Combining letrozole with misoprostol significantly improves complete miscarriage rates with tolerable safety. Letrozole alone is safer but less effective. Thus, combination therapy may offer an optimal non-surgical strategy for individualised management.

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Discussion

Authors

Mohamed Fikry Yousef

Mamdouh Abdelfatah Sheeba

Hany Saad Amin Mohamed

Journals

Sultan Qaboos University medical journal

Actions

Institutions

Columbia University Irving Medical Center

Cairo University

Al-Azhar University

References and Citations

Connected Papers

Building similarity graph...

Analyzing shared references across papers

Efficacy and Safety of Letrozole, Misoprostol and Their Combination in First Trimester Missed Miscarriage: A randomised clinical trial

Key Points

Abstract

Citation Network

Connected Papers

Discussion

Authors

Journals

Actions

Institutions

References and Citations

Citation Network

Connected Papers

Discussion

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