A 12-year retrospective study of myeloproliferative neoplasm patients at Thammasat Hospital

Background: Myeloproliferative neoplasm (MPN) are group of malignant hematologic diseases related to abnormal hematopoietic stem cell, including chronic myeloid leukemia (CML), polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF). Objectives: To study characteristics and survival of each type of MPN patients. Methods: A 12-year retrospective chart review study of MPN patient who attended hematology clinic during Jan 2000 to Dec 2011. Results: There are 64 patients with 26 CML, 18 PV, 19 ET and 1 IMF with a standard treatment i.e. imatinib, nilotinib, hydroxyurea as a targeted and chemotherapeutic agents and aspirin, clopidogrel, cilostazol as an antiplatelets. The 5-yr survival rate was 85.7% with CML, 91.7% with PV, and 90.9% with ET. The overall median survival was 53.9 months with CML, 66 months with PV, 59.7 months with ET, and 48 months with IMF. Conclusion: Myeloproliferative neoplasms are diagnosed sporadically in routine clinical practice in Thammasat Hospital. Signs and symptoms of patients areconsistent with previous study results. Early diagnosis and appropriate treatment plans can improve patient’s survival rate.