March 3, 2026Open Access

Treating myocardial infarction combined with depression via regulating M1/TNF-α/TNFR1/NF-κB

Puntos clave

Myocardial infarction and depression show interlinked pathways through TNF-α and NF-κB, impacting treatment outcomes.
Key evidence indicates that modulation of M1 cells and TNF-α helps mitigate depressive symptoms post-myocardial infarction.

PICO estructurado

Población

Mice with myocardial infarction (MI) and depression

Intervención

ABLP treatment

Resultado

Cardiac dysfunction and depressive behaviorssurrogate

ABLP treatment demonstrates potential in improving cardiac dysfunction and depressive behaviors in a mouse model of myocardial infarction via inflammatory pathway regulation.

Resumen

ABLP treatment exerts beneficial effects in improving cardiac dysfunction and alleviating depressive behaviors in MI mice by inhibiting the M1/TNF-α/TNFR1/NF-κB signaling pathway. The underlying inflammatory response may be associated with cortical 5-HT levels.

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Cite This Study

Zhang et al. (Fri,) studied this question.

synapsesocial.com/papers/69a75f24c6e9836116a2a4c7 https://doi.org/https://doi.org/10.1016/j.bbrep.2026.102471

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