Evidence For a Fibrogenic Interaction Between the Aryl Hydrocarbon Receptor and the Wnt/β-Catenin Pathways in Human Keratinocytes and Fibroblasts

Key Points

• The study reveals a significant interaction between the aryl hydrocarbon receptor and the Wnt/beta-catenin pathway.
• AHR plays a context-dependent role in skin fibrosis, impacting keratinocytes and fibroblasts.
• The investigation highlights the involvement of transforming growth factor beta in these pathways.
• These findings suggest potential targets for therapeutic intervention in skin fibrosis.

Abstract