GZMH+ GZNK+ double positive CD8 T cells: EBV specific t cell expansion in cerebrospinal fluid of multiple sclerosis patients

Key Points

• Increased levels of CD8 T cells were found in cerebrospinal fluid, indicating a strong immune response.
• Specifically, GZMH+ and GZNK+ CD8 T cells showed significant expansion, pointing to their role in EBV response.
• Assessment analyzed cerebrospinal fluid samples from multiple sclerosis patients to reveal immune cell dynamics.
• Findings highlight a potential link between EBV-specific T cell activity and multiple sclerosis pathology.