Our study uncovers a novel therapeutic axis in MASLD, in which PE enhances the stability of PPARα mRNA by directly binding to HNRNPA1, and consequently upregulates fatty acid β-oxidation. These findings not only position PE as a promising therapeutic candidate for MASLD but also identify the HNRNPA1-PPARα regulatory pathway as a potential mechanistic target for treating metabolic liver diseases.
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Yang Zhou
Jingyun Chi
Xining Xu
Phytomedicine
Shanghai Sixth People's Hospital
Suzhou University of Science and Technology
Hangzhou First People's Hospital
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Zhou et al. (Fri,) studied this question.
www.synapsesocial.com/papers/69a75f5fc6e9836116a2ab45 — DOI: https://doi.org/10.1016/j.phymed.2026.157910